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Frequency of expression for each cancer type where red denotes down-regulation, and green denotes up-regulation.
Human Healthy Bulk RNA-seq Expression Overview
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Absent expression
Low expression
Medium expression
High expression
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Healthy bulk RNA-seq for human tissue and the level at which genes are expressed. The silver squares denote absent expression levels, red denotes low expression, green denotes medium expression, and blue denotes high expression.
Mouse Normal Bulk RNA-seq Expression Overview
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Absent
Low Exp Lvl
Medium Exp Lvl
High Exp Lvl
Healthy bulk RNA-seq for mouse tissue and the level at which genes are expressed. The silver squares denote absent expression levels, red denotes low expression, green denotes medium expression, and blue denotes high expression.
Mutation Frequencies by Cancer Type
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Mutation frequencies by cancer types
PEM scores across cell types for various cancers
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High preference
Medium preference
Low preference
★ Cell-type marker gene
This chart displays preferential expression measure (PEM) scores and expression preference types across cancer cell-types for a given gene. PEM assessed the difference between observed and expected expression of a gene in a cell-type with the assumption that the given gene was uniformly expressed in all cell-types of a cancer-type.
Expression Literature mining across different cancers
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Expression literature evidence for the specific gene across different cancers. The green bars represent number of abstracts that mentions the up regulation of the gene while the red bar represent the down regulation of genes.
Percentage of Measured Glycan Intensities for Cirrhosis, HCC, and Transplant for GRN / P28799
No HCC Glycan intensity measurements for this gene
Comparison of the average, normalized MALDI-MS intensity of 50 specific N-glycans for the specified protein in patients with cirrhosis, hepatocellular carcinoma (HCC), or a transplant.
Mutation Literature mining across different cancers
No literature mining results for this gene
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Mutation literature evidence derived from gene mentions in abstracts.
Description: Granulins are a family of secreted_ glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein_ progranulin_ is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active_ 6 kDa peptides. These smaller cleavage products are named granulin A_ granulin B_ granulin C_ etc. Epithelins 1 and 2 are synonymous with granulins A and B_ respectively. Both the peptides and intact granulin protein regulate cell growth. However_ different members of the granulin protein family may act as inhibitors_ stimulators_ or have dual actions on cell growth. Granulin family members are important in normal development_ wound healing_ inflammation_ tissue remodeling and tumorigenesis. Granulins have possible cytokine-like activity.
4-In addition, progranulin is overexpressed in invasive bladder cancer compared to normal tissue controls, suggesting that progranulin might play a key role in driving the transition to the invasive phenotype of urothelial cancer.
GRN
P28799
2896
progranulin
25839164
DOID:11054
urinary bladder cancer
bladder cancer
Sentence_ARG
UP
DISEASE_SAMPLE
invasive bladder cancer tissues compared to normal controls
to normal controls
0
2-In addition, progranulin expression is upregulated in invasive bladder cancer tissues compared to normal controls.
GRN
P28799
2896
GEP
25315249
DOID:684
hepatocellular carcinoma
hcc
Sentence_ARG
UP
DISEASE_SAMPLE
patients with HCC -LRB- n = 80 -RRB-
healthy individuals -LRB- n = 30 -RRB-
0
10-Serum GEP (P = 0.010) and MICA (P < 0.001) levels were higher in patients with HCC (n = 80) than in healthy individuals (n = 30).
GRN
P28799
2896
GP88
25033727
DOID:3908
non-small cell lung carcinoma
nsclc
Sentence_ARG
UP
DISEASE_SAMPLE
stage IIIb/IV NSCLC
control subjects -LRB- 49.9 ng/mL versus 28.4 ng/mL ; P < .0001 -RRB-
0
9-In addition, serum GP88 was significantly elevated in stage IIIb/IV NSCLC compared with control subjects (49.9 ng/mL versus 28.4 ng/mL; P < .0001).
GRN
P28799
2896
PCDGF
22420613
DOID:0050865
tongue squamous cell carcinoma
scc
Sentence_ARG
UP
DISEASE_SAMPLE
SCC or BCC tissues
normal skin or SK
0
6-RESULTS: PCDGF and cyclin D1 were overexpressed in SCC or BCC tissues compared with normal skin or SK, and their expressions were significantly higher in SCC than in BCC.
GRN
P28799
2896
progranulin
19863344
DOID:162
malignant neoplasm
malignant tumors
Sentence_ARG
UP
DISEASE_SAMPLE
malignant tumors
benign tumors and normal ovarian tissue
0
3-Compared with benign tumors and normal ovarian tissue, progranulin mRNA and protein were overexpressed in malignant tumors.
GRN
P28799
2896
proepithelin
19237611
DOID:11054
urinary bladder cancer
bladder cancer
Sentence_ARG
UP
DISEASE_SAMPLE
invasive bladder cancer tissues
normal urothelium
0
7-In support of these in vitro results, we discovered that proepithelin expression was significantly upregulated in invasive bladder cancer tissues compared with normal urothelium.
GRN
P28799
2896
PCDGF
18706200
DOID:3748
esophagus squamous cell carcinoma
escc
Sentence_ARG
UP
DISEASE_SAMPLE
ESCC
normal mucosa
0
6-RESULTS: The expression of PCDGF and VEGF in ESCC was significantly higher than that in normal mucosa.
GRN
P28799
2896
Granulin
28211531
DOID:10283
prostate cancer
gs prostate cancer
Sentence_ARG
UP
DISEASE_SAMPLE
men with high GS prostate cancer -LRB- p-value<0.05 -RRB-
NA
0
9-Granulin, AMBP, CHMP4A, and CHMP4C were also higher in men with high GS prostate cancer (p-value<0.05).
GRN
P28799
2896
progranulin
27220888
DOID:11054
urinary bladder cancer
bladder tumors
Sentence_ARG
UP
DISEASE_SAMPLE
bladder tumors
NA
0
8-Notably, progranulin levels correlated with response to cisplatin treatment and were upregulated in bladder tumors.